Image courtesy Dr. U Hair and Skin Clinic Three severe scalp conditions usually diagnosed separately may represent a single clinical syndrome, according to a small case series that could help physicians identify extensive disease earlier. The study, published in Clinical, Cosmetic and Investigational Dermatology, linked acne keloidalis nuchae (AKN), dissecting cellulitis of the scalp (DCS), and secondary cutis verticis gyrata, or CVG. AKN produces inflammatory papules and thi

BMAL1 (green) and YAP1 (red) in the adult (top) and aged (bottom) epidermis. Cell nuclei appear in blue. Image courtesy the Institute for Research in Biomedicine, Barcelona A new study describes a molecular mechanism that helps explain the drivers of persistent low-grade inflammation that impairs skin regeneration as humans age. Findings show that during aging, two proteins, BMAL1 and YAP, change how they work together and increase the activity of inflammatory genes in the ep

Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signalling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production. Image courtesy Osaka Metropolitan University Researchers report that pi

Robert Harmon, PhD, research assistant professor of Pathology. Photo courtesy Northwestern University Researchers have identified a mechanism that may explain why people with the genetic skin disorder Darier disease often develop symptoms years after birth and experience painful flares triggered by heat, sunlight, and psychological stress. The findings, published in Science Advances, point to oxidative stress and impaired cellular defences as central drivers of Darier disease

Povorcitinib is effective in treating patients with moderate-to-severe HS

Ampyrone increases pigmentation in a human 3D epidermal model, The top row shows visible epidermal darkening after treatment every other day with ampyrone for 21 days as compared to negative control. The bottom row shows magnification of epidermal cells revealing increased melanin synthesis in the ampyrone treated melanocytes as compared to negative control. Positive control is alpha-melanocyte stimulating hormone (αMSH) plus beta-fibroblast growth factor (βFGF). Photo by Dr.

Ali Haider, a graduate student at HU and WPI-SKCM2 and first author of the study, observes the skin structure using confocal microscopy to investigate collagen organization and extracellular matrix remodelling. Photo by Ali Haider / Hiroshima University An international team led by researchers at Hiroshima University has developed a new way to detect subtle, early-stage changes in human skin collagen before any visible signs of damage appear. In the study, published in ACS Na

Shi, S., Zhou, H., Ming, Y. et al. Bionic Cooling Skin for Infected Wound Healing. Nano-Micro Lett. 2026; 18:390. https://doi.org/10.1007/s40820-026-02240-6 CC-BY 4.0 Researchers in Hong Kong and mainland China have developed a bionic “cooling skin” dressing that is reported to protect infected wounds, enhance patient comfort, and deliver on‑demand antibacterial activity. The article was published in Nano-Micro Letters. The team, led by investigators at The Hong Kong Polytech