Squamous cell carcinoma in situ. Photo by Klaus D. Peter via Wikimedia Commons Findings from a preclinical study show a topical cream that blocks the immune-suppressing enzyme LSD1 suppressed tumour growth in two models of cutaneous squamous cell carcinoma (cSCC). The study, published in the  Journal of Clinical Investigation ,  describes how the cream, developed by researchers at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia, prevents LSD1 from suppressing...

Photo by Assianir via Wikimedia Commons Findings from a large population-based study from Finland show that older people with atopic dermatitis (AD) perform worse in measures of several quality of life (QoL) domains, including future outlook, life enjoyment, and anxiety. The University of Oulu, Finland study, published in the Journal of the American Geriatrics Society ,  examined the effects of AD on the quality of life of older people in northern Finland. The research was based on data from...

DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate...