Dermatofibrosarcoma protuberans (DFSP) of the face. Photo by Tontonflingueur via Wikimedia Commons Dermatofibrosarcoma protuberans (DFSP) rarely affects the head and face—but when it does, new research suggests the cheek is the prime location. In what is described as the largest clinical cohort of facial DFSP to date, investigators at a single Chinese institution have mapped the complex distribution of the tumour across facial subunits, uncovering distinct anatomic and biolog

Excess rate (segment width) as the proportion of the sum of all excess rates from crude results from (a) the any-age cohort (i.e., exposed individuals met the eczema definition at any age), (b) the < 18 cohort (exposed individuals met the eczema definition before their 18 th birthday). Each outcome is defined as a 3-character ICD-10 code and its descendants. Labels and increased opacity of segments are shown for outcomes with the largest individual excess rate estimates that

Researchers identify biologics for psoriasis that have better drug survival in bio-naive or bio-experienced patients.

Pustular psoriasis. Photo by Roland Tanglao via Wikimedia Commons Cutaneous paradoxical reactions to biologic therapies for psoriasis and atopic dermatitis are emerging as an important, if unpredictable, complication of these otherwise highly targeted treatments, according to Dr. Jeffrey Marcus Cohen . In a report in the Dec. 2025 issue of The Chronicle of Skin & Allergy , Dr. Cohen noted monoclonal antibodies have transformed care by addressing the underlying immunology of c

Tanning bed use is tied to almost a threefold increase in melanoma risk, and findings from new research show these devices cause melanoma-linked DNA damage across nearly the entire skin surface. The findings were reported in a study published in Science Advances  led by Northwestern Medicine in Chicago and the University of California, San Francisco. This new study “irrefutably” challenges claims from the tanning industry that tanning beds are no more harmful than sunlight by

Patients with chronic skin diseases have higher rates of addictive behaviours.

A new analysis in JAMA Dermatology  reports that nicotinamide, a form of vitamin B3, was associated with a meaningful reduction in incident skin cancers among U.S. veterans with a prior history of the disease. The findings point to an inexpensive, orally administered chemopreventive option that could help clinicians manage an especially high‑risk population. The study drew on data from more than 12,000 veterans followed over 25 years who had previously received nicotinamide a

Tyrosinase (Tyr) catalyzes hydroquinone (HQ) oxidation via two main pathways. The HBQ pathway directly oxidizes HQ to 2-hydroxy-1,4-benzoquinone (HBQ), which dimerizes and forms hydroquinone-eumelanin (HQ-EM). The BQ pathway involves dopaquinone (DQ)-mediated redox exchange producing p-benzoquinone (BQ), which reacts with cysteine (Cys) to form 2-S-cysteinylhydroquinone (Cys-HQ) and further oxidizes to hydroquinone-pheomelanin (HQ-PM). These pathways illustrate the enzymatic