An AI-guided network analysis of genomic data (left) highlights two protein targets, including the oxytocin receptor, identified through Biohub’s CRISPR screen in primary human skin cells (right). Image by Zhao, C., Shih, M., Ahmed, S. et al. Nat Commun (2026). Researchers have combined genome-wide CRISPR screening with artificial intelligence to identify two unexpected therapeutic targets for psoriasis, opening a possible path toward topical treatments that avoid systemic immunosuppression....

In photodynamic therapy, a light-sensitive drug accumulates in cancer cells and is then activated by light, producing cell-killing molecules. Microneedles can help deliver the drug and distribute light more effectively within non-melanoma skin cancer. Image by M. Requena et al. A biodegradable microneedle patch designed to deliver treatment through the skin may also guide and scatter light, potentially allowing photodynamic therapy (PDT) to treat nonmelanoma skin cancers more uniformly,...

Ampyrone increases pigmentation in a human 3D epidermal model, The top row shows visible epidermal darkening after treatment every other day with ampyrone for 21 days as compared to negative control. The bottom row shows magnification of epidermal cells revealing increased melanin synthesis in the ampyrone treated melanocytes as compared to negative control. Positive control is alpha-melanocyte stimulating hormone (αMSH) plus beta-fibroblast growth factor (βFGF). Photo by Dr. Jonathan Zippin...