Dermatologists use the term postinflammatory hyperpigmentation (PIH) to describe darkened skin that remains after an inflammatory disorder has subsided. But the inflammation may not always be over, and a JAMA Dermatology viewpoint argues that the term “postinflammatory” may obscure persistent disease activity, particularly in patients with darker skin tones. Dr. Jerry Tan The authors point out that hyperpigmentation can coexist with ongoing inflammation, particularly in chron

Tyrosinase (Tyr) catalyzes hydroquinone (HQ) oxidation via two main pathways. The HBQ pathway directly oxidizes HQ to 2-hydroxy-1,4-benzoquinone (HBQ), which dimerizes and forms hydroquinone-eumelanin (HQ-EM). The BQ pathway involves dopaquinone (DQ)-mediated redox exchange producing p-benzoquinone (BQ), which reacts with cysteine (Cys) to form 2-S-cysteinylhydroquinone (Cys-HQ) and further oxidizes to hydroquinone-pheomelanin (HQ-PM). These pathways illustrate the enzymatic

CO2 laser treatment significantly improved quality of life in patients with hidradenitis suppurativa

Dr. Jérôme Coulombe When children present with unexplained bumps or masses on their skin, Doppler ultrasound is increasingly becoming the...

Graphical abstract, Shobnam N, et al. Journal of Investigative Dermatology (March 14, 2025, online ahead of print) Researchers at the...

Researchers at NYU Langone Health and its Perlmutter Cancer Center have developed a remote diagnostic tool, SpotCheck, which demonstrates...

There is a significant discrepancy between population demographics and representation in dermatology resources, and a critical need for...

Researchers have validated a novel scale for analyzing hyperpigmentation in a diverse U.S. population of varying skin tones.