Photo by Welshsk via Wikimedia Commons The use of glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used to manage type 2 diabetes mellitus (T2DM) and obesity, appears to increase the risk of nonscarring hair loss (NSHL). These findings were published online ahead of print in the Journal of the American Academy of Dermatology . In the paper, the authors note that emerging reports suggest potential dermatologic adverse effects associated with GLP-1RA use, particular

Photo by Nataliya Melnychuk via Unsplash Regular use of a sunscreen may do more than deflect ultraviolet (UV) rays—it could help preserve the molecular and epigenetic stability of human skin, according to new research. In a study published in Scientific Reports , Agata Bienkowska and colleagues found that consistent sunscreen application can prevent many of the fundamental biological disruptions caused by repeated UV exposure. The findings build on decades of evidence linkin

DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..

Drs. Michael Longaker (L), Derrick Wan (C), and Dayan Li (R). Image courtesy Stanford Medicine News Facial wounds may hold the key to minimizing scarring, according to new preclinical research that studied why the face heals differently than the trunk and extremities. The findings, published Jan. 22, 2026, in Cell , outline a neural crest–derived fibroblast program and a ROBO2–EP300 signalling pathway that together drive a more regenerative, less-fibrotic pattern of repair.​

Pustular psoriasis. Photo by Roland Tanglao via Wikimedia Commons Cutaneous paradoxical reactions to biologic therapies for psoriasis and atopic dermatitis are emerging as an important, if unpredictable, complication of these otherwise highly targeted treatments, according to Dr. Jeffrey Marcus Cohen . In a report in the Dec. 2025 issue of The Chronicle of Skin & Allergy , Dr. Cohen noted monoclonal antibodies have transformed care by addressing the underlying immunology of c

Photo by Svdmolen via Wikimedia Commons Researchers at the University of Arizona have identified a previously unknown population of circulating immune cells that play a critical role in fibrosis. The findings, published in Nature Biomedical Engineering , add to the understanding of the healing process and could lead to new strategies for preventing or treating fibrosis. Fibrosis contributes to nearly half of all deaths in developed countries, including conditions such as pulm

Photo by Judit Peter via Pexels The submission deadline for the 4th annual short essay competition on the topic of Inclusivity, Diversity and Equity in Dermatology is Dec. 4, 2025. The contest is open to any qualified resident enrolled in a dermatology training program at a Canadian medical school. This essay competition is organized by the Dermatology Industry Taskforce on Inclusion, Diversity and Equity (DiTiDE), an unincorporated, "ad hoc" committee consisting of Canadi

The FPR1-inhibitory activity of the candidate compounds was evaluated using an in vitro SJS/TEN assay. Cell death inhibition was assessed by live/dead staining following treatment with various concentrations of each compound. Among the seven candidates, CDCA exhibited a specific and potent inhibitory effect on cell death, even at low concentrations. Image modified from Kimura H et al., Nat Commun . 2025. A Japanese research group has identified a promising therapeutic candida