DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..

Drs. Michael Longaker (L), Derrick Wan (C), and Dayan Li (R). Image courtesy Stanford Medicine News Facial wounds may hold the key to minimizing scarring, according to new preclinical research that studied why the face heals differently than the trunk and extremities. The findings, published Jan. 22, 2026, in Cell , outline a neural crest–derived fibroblast program and a ROBO2–EP300 signalling pathway that together drive a more regenerative, less-fibrotic pattern of repair.​

Pustular psoriasis. Photo by Roland Tanglao via Wikimedia Commons Cutaneous paradoxical reactions to biologic therapies for psoriasis and atopic dermatitis are emerging as an important, if unpredictable, complication of these otherwise highly targeted treatments, according to Dr. Jeffrey Marcus Cohen . In a report in the Dec. 2025 issue of The Chronicle of Skin & Allergy , Dr. Cohen noted monoclonal antibodies have transformed care by addressing the underlying immunology of c

Photo by Svdmolen via Wikimedia Commons Researchers at the University of Arizona have identified a previously unknown population of circulating immune cells that play a critical role in fibrosis. The findings, published in Nature Biomedical Engineering , add to the understanding of the healing process and could lead to new strategies for preventing or treating fibrosis. Fibrosis contributes to nearly half of all deaths in developed countries, including conditions such as pulm

Photo by Judit Peter via Pexels The submission deadline for the 4th annual short essay competition on the topic of Inclusivity, Diversity and Equity in Dermatology is Dec. 4, 2025. The contest is open to any qualified resident enrolled in a dermatology training program at a Canadian medical school. This essay competition is organized by the Dermatology Industry Taskforce on Inclusion, Diversity and Equity (DiTiDE), an unincorporated, "ad hoc" committee consisting of Canadi

The FPR1-inhibitory activity of the candidate compounds was evaluated using an in vitro SJS/TEN assay. Cell death inhibition was assessed by live/dead staining following treatment with various concentrations of each compound. Among the seven candidates, CDCA exhibited a specific and potent inhibitory effect on cell death, even at low concentrations. Image modified from Kimura H et al., Nat Commun . 2025. A Japanese research group has identified a promising therapeutic candida

Human fungal infection (Dermatophytosis/Mycosis) on the forearm. Photo by Asurnipal via Wikimedia Commons Nearly half of people living with HIV continue to experience skin conditions, despite major advances in antiretroviral therapy, according to new research led by investigators at George Washington University. The study, published through the DC Cohort—a major longitudinal project tracking HIV outcomes in the Washington, D.C. area—reviewed medical records from 11,738 adults

Stefania Nicoli, PhD. Photo courtesy Yale School of Medicine The outer surface of the skin, noted for its regenerative processes, may owe its resilience to lessons learned before birth. In a study published October 10 in Nature Communications , researchers at Yale School of Medicine report that embryonic skin stem cells establish the physical and molecular groundwork that allows the body to repair itself throughout life. Led by Kaelyn Sumigray, PhD, and Stefania Nicoli, PhD,