Photo by Eisfelder via Wikimedia Commons New research has documented a significant impact of severe atopic dermatitis (AD) on a child’s height, and that dupilumab treatment can help improve growth. The study, published in the Journal of the American Academy of Dermatology, investigated the effect of a medication commonly used to treat AD on growth and bone biomarkers in 123 children aged six to 11 years with severe eczema. Researchers found that children who had severe AD and

Conversation cards may be an effective way to support patient-centred HS care

Dermatologists use the term postinflammatory hyperpigmentation (PIH) to describe darkened skin that remains after an inflammatory disorder has subsided. But the inflammation may not always be over, and a JAMA Dermatology viewpoint argues that the term “postinflammatory” may obscure persistent disease activity, particularly in patients with darker skin tones. Dr. Jerry Tan The authors point out that hyperpigmentation can coexist with ongoing inflammation, particularly in chron

BMAL1 (green) and YAP1 (red) in the adult (top) and aged (bottom) epidermis. Cell nuclei appear in blue. Image courtesy the Institute for Research in Biomedicine, Barcelona A new study describes a molecular mechanism that helps explain the drivers of persistent low-grade inflammation that impairs skin regeneration as humans age. Findings show that during aging, two proteins, BMAL1 and YAP, change how they work together and increase the activity of inflammatory genes in the ep

Zasocitinib is effective in improving skin clearance for PsO patients in hard-to-treat areas with once-daily treatment

Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signalling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production. Image courtesy Osaka Metropolitan University Researchers report that pi

Robert Harmon, PhD, research assistant professor of Pathology. Photo courtesy Northwestern University Researchers have identified a mechanism that may explain why people with the genetic skin disorder Darier disease often develop symptoms years after birth and experience painful flares triggered by heat, sunlight, and psychological stress. The findings, published in Science Advances, point to oxidative stress and impaired cellular defences as central drivers of Darier disease

Povorcitinib is effective in treating patients with moderate-to-severe HS