DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..

Researchers recently reviewed the relative efficacy of 22 immunomodulatory treatments for scalp psoriasis.

Drs. Michael Longaker (L), Derrick Wan (C), and Dayan Li (R). Image courtesy Stanford Medicine News Facial wounds may hold the key to minimizing scarring, according to new preclinical research that studied why the face heals differently than the trunk and extremities. The findings, published Jan. 22, 2026, in Cell , outline a neural crest–derived fibroblast program and a ROBO2–EP300 signalling pathway that together drive a more regenerative, less-fibrotic pattern of repair.​

Photo by AfroBrazilian via Wikimedia Commons A new study, published in JMIR Dermatology , has identified a disconnect between how patients with atopic dermatitis (AD) experience climate-related triggers and how often these concerns are addressed in clinical care. The researchers say their findings underscore a need for tools and strategies to support climate-health conversations in dermatology. For the study, investigators initially selected 2,164 English-speaking adults with

Healthy diets full of plant-based foods have been shown to decrease the risk of rosacea.

Dermatofibrosarcoma protuberans (DFSP) of the face. Photo by Tontonflingueur via Wikimedia Commons Dermatofibrosarcoma protuberans (DFSP) rarely affects the head and face—but when it does, new research suggests the cheek is the prime location. In what is described as the largest clinical cohort of facial DFSP to date, investigators at a single Chinese institution have mapped the complex distribution of the tumour across facial subunits, uncovering distinct anatomic and biolog