Pachyonychia congenita. Photo by Ali87090 via Wikimedia Commons Pachyonychia congenita (PC) is a rare genetic disorder caused by mutations in one of five keratin genes. PC produces debilitating plantar calluses and a characteristic thickening of the nails, with no approved treatment options. In a paper in Science Translational Medicine , University of Michigan investigators report that a single stress‑induced keratin, keratin 16 (K16), may help explain why the skin’s response

Photo by Gzzz via Wikimedia Commons For the first time, the American Academy of Dermatology (AAD) has published guidelines for the prevention and management of atopic dermatitis (AD) in pediatric patients. A press release from the Academy notes that while pediatric and adult AD share similarities, the new guidelines recognize the unique safety, dosing, and patient-caregiver-clinician interactions of individuals under the age of 18. “Eczema is extremely common in children, th

Loneliness is linked in patients with chronic leg and foot wounds to an increased expression of genes related to inflammation.

Botulinum toxin may offer a practical new option for patients with painful, treatment‑resistant ischemic lesions of the fingers, according to a systematic review and individual‑patient meta‑analysis published in JAMA Dermatology  by investigators at the McGill University Health Centre (MUHC) in Montreal. Researchers at the Research Institute of the MUHC report that injections of botulinum toxin were associated with complete healing of digital lesions in more than 85% of 119 p

There are no associations between AD and cardiovascular risk factors in children and adolescents.

Photo by Benis Arapovic via Vecteezy Researchers in Arkansas are developing experimental surgical sutures that slowly release anti-inflammatory drugs at the wound site, aiming to curb local inflammation, reduce scarring, and potentially improve outcomes of delicate procedures. Working in the laboratory of chemist Sharon K. Hamilton, PhD, at Ouachita Baptist University, undergraduate researcher Mieya Kirby has focused on electrospun polymers, which can be drawn under high volt

Mastocytosis. Photo by Doc James via Wikimedia Commons Recent findings show treatment with the selective KIT D816V inhibitor avapritinib for indolent systemic mastocytosis (ISM) improved dermatologic symptoms, decreased skin lesion size, normalized skin lesion colour, and reduced skin mast cell burden. The study was published in the Journal of the American Academy of Dermatology . In a press release , the study’s senior author, Karin Hartmann, MD, said that her mastocytosis p

Upadacitinib was significantly effective in treating AD and modestly effective in treating HS