Immune trajectory shifts in the pre- to post-radiotherapy (RT) tumour microenvironment in cutaneous T-cell lymphoma. Courtesy of Alan Zhou, MD, ‘21 MSc. Researchers have discovered how radiotherapy alters the immune environment within cutaneous T-cell lymphoma (CTCL) tumours, according to findings published in the Journal of the American Academy of Dermatology. The study reveals how radiotherapy not only eliminates cancer cells but also reprograms the surrounding tumour micro

DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..