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Neural mechanism signals the body to stop scratching

TRPV4, an ion channel, is found in neurons classically associated with touch, called Aβ low-threshold mechanoreceptors. New research indicates that TRPV4 can generate itch, but it also helps trigger a negative feedback signal, a neural message that tells the spinal cord and brain that scratching has been sufficient. Image Courtesy of Roberta Gualdani Researchers have discovered that the ion channel TRPV4 plays a critical role in regulating the body's built-in "stop-scratching

Allan Ryan

Feb 232 min read

Advanced treatments for psoriasis, AD may produce paradoxical reactions

Pustular psoriasis. Photo by Roland Tanglao via Wikimedia Commons Cutaneous paradoxical reactions to biologic therapies for psoriasis and atopic dermatitis are emerging as an important, if unpredictable, complication of these otherwise highly targeted treatments, according to Dr. Jeffrey Marcus Cohen . In a report in the Dec. 2025 issue of The Chronicle of Skin & Allergy , Dr. Cohen noted monoclonal antibodies have transformed care by addressing the underlying immunology of c

Allan Ryan

Jan 192 min read

Early family life stress raises psoriasis risk

New longitudinal research reveals that severe stress caused by changes in family structure—such as divorce or separation—experienced during the first year of life may triple the risk of developing psoriasis later in life. The results of the study, published in the Journal of Investigative Dermatology , emphasize the need to protect young children from stressful life factors that threaten their security and emotional well-being. According to a press release , this is the first

John Evans

Oct 24, 20252 min read