Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signalling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production. Image courtesy Osaka Metropolitan University Researchers report that pi

Nevus of Ota. Photo by Mohammad2018 via Wikimedia Commons Researchers have developed an in silico mathematical model of picosecond laser...