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Gut microbiome patterns predict melanoma recurrence after immunotherapy
Image by freepik The composition of gut bacteria can predict which melanoma patients will experience cancer recurrence after surgical resection and immunotherapy, but only when matched to patients with similar microbial profiles, according to research published April 17 in Cell. The findings from a 674-patient international clinical trial offer a novel approach to stratifying recurrence risk in high-risk melanoma patients undergoing adjuvant immune checkpoint blockade. Resear
Allan Ryan
May 112 min read


Peripheral nerves may inhibit melanoma growth
Nerves (in green) within a melanoma tumour. Photo by: Dr. David J. Simon Nerve fibres within melanomas can slow tumour growth, according to a study led by Weill Cornell Medicine investigators. The findings help clarify the emerging field of cancer neuroscience and may inform future therapeutic strategies. In the study, published April 29 in Neuron, the researchers used mouse models of melanoma to examine the presence and the effects of peripheral nerves that grow into tumours
John Evans
May 13 min read


Pro-inflammatory M1 macrophages induce an inflammatory, invasive phenotype in melanoma cells
Melanoma cells with the cell membrane protein CD44 stained in red and the nucleus in blue. Dil-labelled extracellular vesicles taken up by cancer cells are shown in green. Image by Kaisa Mäki-Mantila. Pro-inflammatory macrophages may do more than mark an inflamed tumour microenvironment; they may help drive melanoma toward a more invasive phenotype, according to new data from the University of Eastern Finland. The findings, published in Cell Communication and Signaling , posi
Allan Ryan
Mar 92 min read


Immunotherapy effective for rare melanoma, study finds
Dr. Antoni Ribas, senior author of the study and director of the UCLA Health Jonsson Comprehensive Cancer Center’s Tumour Immunology...
Derm City
Aug 18, 20252 min read


At-home melanoma detection? Microneedle skin patch under development
The newly designed ExoPatch, being removed from a sample of mouse skin, successfully distinguished melanoma from healthy skin in mice. A...
Allan Ryan
Aug 11, 20252 min read


Study shows EGFR inhibitors may be effective in melanoma that does not respond to standard treatments
A newly published study from NYU Langone Health and the Perlmutter Cancer Center suggests a promising avenue of treatment for patients...
Allan Ryan
Jul 28, 20252 min read
AI outperforms pathologists in quantifying tumour-infiltrating lymphocytes in melanoma
A multinational study led by Yale School of Medicine and the Karolinska Institute in Sweden has found that artificial intelligence...
Allan Ryan
Jul 21, 20252 min read


Most patients with advanced melanoma remain disease-free four years after pre-surgical immunotherapy
Elizabeth Burton, PhD. Photo courtesy The University of Texas MD Anderson Cancer Center In a significant advance for the management of...
Allan Ryan
Jul 14, 20252 min read
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