Under normal conditions (left), melanocytes adhere to laminin-211 in the basement membrane through dystroglycan, maintaining their mature pigment-producing state. In vitiligo (right), remodeling of the basement membrane increases laminin-332 and promotes integrin α3β1-mediated adhesion, activating signalling pathways, including c-Jun, that drive melanocyte dedifferentiation and loss of pigment production. Image courtesy Osaka Metropolitan University Researchers report that pi

Photo by Thirunavukkarasye-Raveendran via Wikimedia Commons JAK inhibitors are emerging as effective treatments for alopecia areata, said...

Researchers have successfully treated seven patients experiencing toxic epidermal necrolysis (TEN) using JAK inhibitors. All seven...

New research shows that the Janus kinase (JAK) inhibitor abrocitinib, approved in Canada for the treatment of moderate-to-severe atopic...

A study from the Icahn School of Medicine at Mount Sinai in New York has reported some new insights into JAK inhibitors. While current...

New findings suggest that eosinophilic cellulitis (EC) preferentially activates the Janus kinase (JAK) 1/JAK2-STAT5 pathways. The...

Researchers have identified genomic variants that cause disabling pansclerotic morphea and have identified a treatment for the rare,...

New findings show that the oral Janus kinase (JAK) inhibitor ritlecitinib effectively treats alopecia areata in adolescents. The study...