Pachyonychia congenita. Photo by Ali87090 via Wikimedia Commons Pachyonychia congenita (PC) is a rare genetic disorder caused by mutations in one of five keratin genes. PC produces debilitating plantar calluses and a characteristic thickening of the nails, with no approved treatment options. In a paper in Science Translational Medicine , University of Michigan investigators report that a single stress‑induced keratin, keratin 16 (K16), may help explain why the skin’s response

Yu-Ying He, PhD. Photo courtesy the University of Chicago In a new study published in Nature Communications , researchers at the University of Chicago have discovered how prolonged exposure to ultraviolet (UV) radiation can trigger inflammation in skin cells by degrading a key protein called YTHDF2. This protein acts as a gatekeeper in preventing normal skin cells from becoming cancerous. The finding reveals that YTHDF2 plays a crucial role in regulating RNA metabolism to mai

Photo by: Haley Otman via Wikimedia Commons Researchers at Case Western Reserve University School of Medicine in Cleveland have...

New research supports the hypothesis that air pollution may contribute to the development or worsening of skin conditions. The work,...

The results of a small study indicate that third-hand smoke (THS)—the incinerated particles of smoke that settle on clothing and other...

Researchers have found that the hormone estradiol suppresses psoriasis, providing a basis for therapeutic potential.

Mild atopic dermatitis may not trigger systemic immune activation, according to a new study.