Pachyonychia congenita. Photo by Ali87090 via Wikimedia Commons Pachyonychia congenita (PC) is a rare genetic disorder caused by mutations in one of five keratin genes. PC produces debilitating plantar calluses and a characteristic thickening of the nails, with no approved treatment options. In a paper in Science Translational Medicine , University of Michigan investigators report that a single stress‑induced keratin, keratin 16 (K16), may help explain why the skin’s response

Sun exposure has long been viewed as the primary risk factor for skin cancer, with inherited genes playing a relatively minor role. But a...

Researchers have identified the mechanisms behind mutations that cause the congenital condition known as aplasia cutis congenita...

Psoriasis is not caused or spread by spontaneous genetic mutations in the skin, new research suggests. These findings come from a study...

A study from the University of Alberta has identified genetic mutations in scleroderma patients, a finding that may lead to new...