DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..

Women and people aged 30 to 69 years may be at higher risk of developing a delayed large local reaction (DLLR) after receiving the...

In a new study, researchers from Seoul, South Korea have found that underlying skin disorders do not predispose patients to Covid-19.