TRPV4, an ion channel, is found in neurons classically associated with touch, called Aβ low-threshold mechanoreceptors. New research indicates that TRPV4 can generate itch, but it also helps trigger a negative feedback signal, a neural message that tells the spinal cord and brain that scratching has been sufficient. Image Courtesy of Roberta Gualdani Researchers have discovered that the ion channel TRPV4 plays a critical role in regulating the body's built-in "stop-scratching

New findings show that patients with chronic pruritus of unknown origin (CPUO) have lower-than-normal levels of some metabolite...

A new study published in the British Journal of Dermatology has revealed that people with chronic pruritus are twice as likely to...

A new study has identified what may be the first biomarker for chronic itch. Published in Drugs in Dermatology, researchers from the...