First author Yuhua Tian, front, and senior author Jie Zheng in the Zheng lab on the UC Davis campus. Photo courtesy Regents of the University of California Body temperature may determine whether a single overactive ion channel causes a localized skin disorder or even a potentially lethal arrhythmia, according to new research published in the Proceedings of the National Academy of Sciences (PNAS). In a mechanistic study of TRPM4 gain‑of‑function mutations, investigators at the