BMAL1 (green) and YAP1 (red) in the adult (top) and aged (bottom) epidermis. Cell nuclei appear in blue. Image courtesy the Institute for Research in Biomedicine, Barcelona A new study describes a molecular mechanism that helps explain the drivers of persistent low-grade inflammation that impairs skin regeneration as humans age. Findings show that during aging, two proteins, BMAL1 and YAP, change how they work together and increase the activity of inflammatory genes in the ep