Shoshana Marmon, MD, PhD Some improvements seen in skin thickness and collagen, but study designs varied Topical estrogen is emerging as a sought-after option for menopausal skin changes, but dermatologists caution that the evidence base remains limited and safety questions unresolved, according to a cover article in the Feb. 2026 issue of The Chronicle of Skin & Allergy . Patient interest in facial estrogen preparations has grown in parallel with menopause-focused marketing