MFSD2A is required for the uptake of LPCs containing linoleic acid (LPC18:2) from the blood for normal development of the epidermis. The absence of MFSD2A leads to increased skin inflammation and thickening of the epidermis. Photo by: Bernice Wong Researchers at Duke-NUS Medical School in Singapore have pinpointed a lipid transporter that enables epidermal cells to import key fatty acids from the bloodstream, a mechanism they say is critical for preserving skin barrier integr

DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate..

Dr. Niroshana Anandasabapathy. Photo courtesy Weill Cornell Medicine Researchers have discovered that the immune-regulating molecule...

Photo by: Produnis via Wikimedia Commons Early research suggests a compound derived from bacteria significantly slows the progression of...