Photo by Assianir via Wikimedia Commons Findings from a large population-based study from Finland show that older people with atopic dermatitis (AD) perform worse in measures of several quality of life (QoL) domains, including future outlook, life enjoyment, and anxiety. The University of Oulu, Finland study, published in the Journal of the American Geriatrics Society ,  examined the effects of AD on the quality of life of older people in northern Finland. The research was based on data from...

DKK3 in keratinocytes orchestrates radiation-induced skin hyperplasia, dermatitis, and fibrosis. Radiation-induced reactive oxygen species (ROS) increase DKK3 expression in keratinocytes, which subsequently activates canonical Wnt signaling through autocrine TGF-β signaling. Elevated DKK3 levels in keratinocytes drive hyperproliferation and hyperplasia, promoting the polarization of macrophages toward a profibrotic phenotype. These polarized macrophages, in turn, upregulate...

Excess rate (segment width) as the proportion of the sum of all excess rates from crude results from (a) the any-age cohort (i.e., exposed individuals met the eczema definition at any age), (b) the < 18 cohort (exposed individuals met the eczema definition before their 18 th birthday). Each outcome is defined as a 3-character ICD-10 code and its descendants. Labels and increased opacity of segments are shown for outcomes with the largest individual excess rate estimates that cumulatively...