“During normal wound healing, collagen acts as a scaffold for cellular entry and growth in the wound bed and encourages the deposition of new collagen,” said senior author Dr.Adam Friedman, in a press release. “While collagen has been used as a wound healing adjuvant, a good comparison to the standard of wound care has been lacking.”
In the press release, Professor Ågren said: “The most frequent response we had from participants was: ‘where can I buy this fantastic product?.’ Even though it contained no fragrance like conventional deodorants, the participants could identify that it had neutralized any bad odour under the arm where it was applied."
The current practice to evaluate NO activity in wounds is to measure nitrite, a byproduct of NO, as a proxy, as it is more stable. However that very stability means nitrite does not provide a time signature, so is not useful for measuring NO-related wound healing status in real time, said Dr. Frost.
In 2015, researchers discovered that during the wound healing process, an enzyme called fidgetin-like 2 (FL2) delays skin cells from migrating to wounds. They hypothesized that reducing FL2 levels may enable healing cells to reach their destination faster. As such, the investigators designed small interfering RNA molecules (siRNAs) that specifically inhibit the gene that codes for FL2. When the siRNAs were p...
“Based on our findings, e-cigarettes are not a safe alternative to traditional cigarettes as it relates to timely wound healing,” said Dr. Jeffrey Spiegel, chief of facial plastic surgery at Boston Medical Center.
With this in mind, the team then took tissue samples from young and old mice and compared their gene expression signatures. Eighty differences were identified, which were narrowed down to 13 signatures once they isolated the gene products present in the bloodstream. One of the signatures was SDF1. Considering its known links to tissue scarring, SDFI was the most promising option for the scientists. They conf...
"We think this device could be easily adapted to monitor ulcers remotely using cameras,” said lead author Dr. Michael Hughes. “They could also be programmed to recognize different parts of the body so that the treatment is given accurately.”
Dr. Ameer and his colleagues incorporated A5G81 into an antioxidant hydrogel bandage they had previously developed. The bandage counters inflammation because of its antioxidant nature. The hydrogel is thermally responsive—it is a liquid when applied to the wound bed, then rapidly solidifies into a gel when exposed to body temperature.