A study of stem cells in the development and life of sebaceous glands has shed new light into how these structures form in the skin, how they are replenished during their operational life, and how certain cancer-inducing mutations impact stem cells in these glands.
“Blood vessels are vital because tumours can’t grow without them—they feed the tumours and allow the cancer to spread,” said senior author Professor Kiarash Khosrotehrani. “If you get rid of these stem cells, then the blood vessels don’t form and the tumours don’t grow or spread to other locations.”
“In addition to the major epidermal and dermal cell types we also found specialized cell types, such as melanocytes, Merkel cells, adipocytes, sebaceous gland cells, and hair follicle stem cells in organoids,” Dr. Koehler said. “This is fascinating because it shows that if we derive the basic building blocks of skin together in culture, then these diverse cell types will self-assemble on their own.”
A new technique for combining pre-vascularized sheets of dermal stem cells with split-thickness skin grafts (STSG) may improve the treatment of large, full-thickness burn wounds, according to findings published in Theranostics (2017; 7(1):117–131).
Researchers from Michigan Technological University in Houghton, Mich., and First Affiliated Hospital of Sun Yat-sen University in Guangzhou, China noted in the pap...
Invasive basal cell carcinomas [BCCs] appear to only arise where a skin stem cell is the site of the original oncogenic mutation, while lesions that originate from progenitor cells remain benign, researchers suggest in a study published online in Nature (July 8, 2016).
In order to understand the changes in cell dynamics that follow an oncogenic mutation, which the authors note are currently unknown, invest...
Stem cells respond to mechanical forces by changing their structure The actin cytoskeleton (in green) is able to remodel and strengthen in response to strain. As the cytoskeleton is directly linked to the nucleus and thereby to DNA (in blue), mechanical forces are transmitted onto DNA, changing its structural organization and gene expression. Picture by Huy Quang Le, University of Cologne
Data suggest that the infusion of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) might be an effective therapy for patients with moderate-to-severe atopic dermatitis (AD), researchers reported online in Stem Cells (June 3, 2016).
In order to establish the safety and efficacy of hUCB-MSCs in AD, 34 adult patients with moderate-to-severe AD were enrolled in two trials with a follow-up of...