“The activity of the MITF gene determines the melanoma cells’ specific characteristics, which are then linked to the disease prognosis. The lower the level of DDX3X protein the patient has in the tumour cell, the more aggressive the disease and the worse the prognosis will be,” said Prof. Göran Jönsson
Dermatologists suggest seeking shade, wearing protective clothing and applying water-resistant sunscreen with an SPF of 30 or higher. A recent survey conducted by the AAD found that individuals are applying sunscreen incorrectly leaving them vulnerable to the sun’s dangerous UV rays.
“When human melanoma cell lines were evaluated for growth effects using the chemical inhibitor of p300 HAT, the cell lines that were most sensitive to drug treatment were those that expressed high levels of oMITF, suggesting that MITF expression levels can predict melanoma sensitivity to such therapies,” said Dr. Rhoda Alani.