“The novelty is that [the new lipid vesicles] enable the absorption of a drug of greater size than usual through the skin and opens a route of administration of other substances for therapeutic, diagnostic or even vaccination purposes through the intact skin, without having to be injected," said lead author Ana Melero, PhD.
“It is important to consider that visible and infrared light may also be contributing to the damage our skin receives from the sun, and that it could be beneficial to protect our skin against these as well when UV is present,” said Professor Mark Birch-Machin
“We created the platform to provide new information to drug makers to help them better understand the amount of pain a certain injectable medication may cause a patient,” Han said. “They can then work to design and optimize the drug formulations or injection devices to minimize the pain associated with injection.”
“These data demonstrate the therapeutic benefit of blocking Vegfa/Nrp1 interaction in the treatment of psoriatic disease, which may be safer for the treatment of psoriasis as compared to other therapeutic modalities that can be associated with serious side effects,” said Dr. Cédric Blanpain, the senior author of this study.