“When human melanoma cell lines were evaluated for growth effects using the chemical inhibitor of p300 HAT, the cell lines that were most sensitive to drug treatment were those that expressed high levels of oMITF, suggesting that MITF expression levels can predict melanoma sensitivity to such therapies,” said Dr. Rhoda Alani.
The Organizing Committee of the 4th Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) has issued a call for abstracts to be included in the symposium as either oral or poster presentations. The deadline for submission is Friday, July 5, and abstracts must be submitted online to www.shsaabstracts.com. Mailed or emailed abstracts will not be accepted.
A new study which sought to determine just how prevalent skin diseases really are outside of a medical setting has found that more than two thirds of a sample of people attending a large public social event had one or more skin issues--a rate much higher than the rate at which individuals present to medical professionals with skin complaints.
“Until recently, the scientific community didn’t believe that skin could contribute to systemic inflammation and disease. But in the last five years, studies of psoriasis and dermatitis have shown that skin inflammation from these diseases likely increases the risk of heart disease,” said study lead author Dr. Theodora Mauro
Furthermore, investigators isolated patterns in how melanoma develops resistance to PD-1 inhibitors after surgery, which may lead to deeper understanding of how to best treat patients in the future. Researchers identified two causes: tumour mutations—such as B2M or TP53—as well as increased activity of cells that naturally suppress the immune system.
This Spring, The Chronicle of Skin & Allergy will publish a special commemorative edition titled Women in Dermatology, showcasing the significant contributions women make to the profession of dermatology in Canada.
“What makes this trial even more ground-breaking is that the children in the home group were never even admitted to hospital,” said co-senior author Penelope Bryant, PhD. Dr. Bryant is an associate professor and head of the RCH Hospital-in-the-Home program.