A major motivator for the investigators is the historical lack of diversity in genetics research. For example, the first major study on the genetics of skin tone diversity in Africa occurred only recently. Latin Americans are similarly underrepresented in genetics research, particularly in pigmentation research.
“It’s a different world now in metastatic melanoma, because instead of the traditional cytotoxic chemotherapy that not only kills cancer cells but also kills normal cells, we’re stimulating the immune system to attack the cancer cells.”
“While melanin-targeted PET probes have been studied in small animal models for a long time, this is the first time such a probe has been successfully translated into clinical evaluation,” the paper’s senior author Zhen Cheng, PhD, explained.
“While skin infections are not a reason to cancel your gym membership, it is important to follow a few simple steps to avoid germs while you are at the gym,” said Dr. Brian Burke Adams, professor and chair of dermatology at the University of Cincinnati in Ohio.
“We were surprised to see that metabolic abnormalities were predominant and consistently found in patients with skin fibrosis, even years after their original radiotherapy,” said Dr. Zhao. “Our question was: ‘Can we manipulate metabolism to reduce fibrosis?’”