In 2015, researchers discovered that during the wound healing process, an enzyme called fidgetin-like 2 (FL2) delays skin cells from migrating to wounds. They hypothesized that reducing FL2 levels may enable healing cells to reach their destination faster. As such, the investigators designed small interfering RNA molecules (siRNAs) that specifically inhibit the gene that codes for FL2. When the siRNAs were p...
"Based on the results of this study, the use of topical agents just before radiation therapy can be safely liberalized, which may improve quality of life for patients undergoing radiation therapy, but very thick applications of topical agents just before radiation therapy should still be avoided,” Dr. Baumann said.
In future studies, the researchers will replicate the trial in sample populations with non-European heritage. They are also exploring alternative techniques of calculating genetic risk score and measuring sun exposure, with the goal of developing risk estimates accurate enough to be used by clinicians and patients.
“Based on our findings, e-cigarettes are not a safe alternative to traditional cigarettes as it relates to timely wound healing,” said Dr. Jeffrey Spiegel, chief of facial plastic surgery at Boston Medical Center.
The online model allowed 148 of the patients and primary care physicians to interface via computer, though not in real time. Dermatologists provided assessments, recommendations, education, and prescriptions online.
The survey also uncovered the top five treatments among the survey participants. The percentages of respondents who have had previous treatments include: ultrasound, laser, light and radiofrequency treatments for smoothing skin (57%), body sculpting (57%), microdermabrasion (51%), laser hair removal (48%), and injectable wrinkle-relaxing injections (47%).
“For years scientists have been trying to solve the mystery of how gentle touch becomes painful. These results suggest PIEZ02 is the gene for tactile allodynia. We hope that these results will help researchers develop better treatments for managing this form of pain,” said Alexander T. Chesler, PhD.
The investigators also analyzed the effect of sun exposure on cell mutations. Very low doses of ultraviolet light—below sunburn level—were shone onto the mice with mutated p53 genes. The mutated cells grew much faster. They reached the level of growth seen at six months in non-UV radiated clones in only a few weeks. Despite this rapid growth, the mice did not develop skin cancer nine months after exposure.