“In addition to the major epidermal and dermal cell types we also found specialized cell types, such as melanocytes, Merkel cells, adipocytes, sebaceous gland cells, and hair follicle stem cells in organoids,” Dr. Koehler said. “This is fascinating because it shows that if we derive the basic building blocks of skin together in culture, then these diverse cell types will self-assemble on their own.”
The G protein-coupled estrogen receptor (GPER), once activated and combined with anti programmed death(PD)-1 inhibitor therapies, extended survival rate and eliminated tumours in 50% of cancer mouse models that have had three consecutive pregnancies, according to a study. This may explain why female sex and pregnancy hormones provide an advantage against melanoma.
“The fact that LIGHT acts upstream of periostin and is controlling its production really reinforces the idea that this is potentially a very good clinical target for treatment of atopic dermatitis and other inflammatory skin diseases,” said Michael Croft, PhD.
Myeloablative CD34+ autologous stem cell transplant is an effective treatment for severe scleroderma, otherwise known as diffuse cutaneous systemic sclerosis, according to a study published online ahead of print in The New England Journal of Medicine (Jan. 4, 2018).
The experimental treatment involves extracting hematopoietic stem cells from the patient’s blood which are stored in a freezer. Then, the patient...
“Our findings challenge the previous school of thought that immunotherapy would offer little benefit to patients with desmoplastic melanoma due to the dense tissue architecture of these tumors,” said lead author Dr. Zeynep Eroglu, in a press release from the Moffitt Cancer Center in Tampa, Fla.
Using the generic skin cream fluorouracil 5% (5-FU) for two to four weeks may reduce the risk of a squamous cell carcinoma (SCC) needing surgery by 75%. A single course of 5-FU reduced surgery for SCC for up to one year. The results come from a study published online in the journal JAMA Dermatology (Jan. 3, 2018) which involved military veterans at high risk for keratinocyte carcinoma. A total of 932 veteran...
“Our results suggest people with HLA-DQB1*03:01 have a higher risk of developing BP when exposed to DPP-4i than those without the HLA gene. The gene could serve as a biomarker to help estimate the risk of developing BP when patients are administered with DPP-4i."