T-helper 17 (Th17) immune cells appear to play a key role in the inflammation associated with hidrandenitis suppurativa (HS), suggesting the Th17 pathway may be a therapeutic target for treatment of the skin condition.
The research was performed by a team of researchers from Trinity College Dublin, St. Vincent’s University Hospital, Elm Park, Ireland, and Tallaght Hospital, Tallaght, Ireland.
A multi centre chart review examining data on patients treated with biologic therapies for psoriasis has found that while treatment adherence dropped off over the five years patients were tracked, adherence was significantly higher for ustekinumab compared to the other three therapies evaluated.
With an increase in international travel and new mass migration and immigration patterns, health care providers in developed countries need to become familiar with tropical skin diseases in order to ensure optimized care for returning travellers or immigrants. That is according to the authors of a report published in Pediatric Dermatology (June 2016; 33(3):253– 274).
A team of researchers from Nagoya University in Japan have defined a new type of inflammatory keratinization disorder with autoinflammatory pathogenic mechanisms, which they suggest will improve diagnosis and treatment of rare skin conditions.
A perturbed skin microbiome resulting from cutaneous leishmaniasis can be ‘contagious’, promoting skin inflammation in other subjects, researchers from the University of Pennsylvania report online in Cell Host & Microbe (June 29, 2017).
In their research, the investigators found that human patients infected with Leishmania braziliensis develop imbalances in the microbiota on their skin - dysbiosis – characte...
The SOLO 1 and SOLO 2 phase 3 trials of the human monoclonal anti-body dupilumab for the treatment of eczema/atopic dermatitis (AD) have shown a high degree of efficacy and safety.
Those outcomes, according to one investigator, represent the first evidence for a treatment that can reliably improve out comes in patients with AD who require a systemic therapy to control their disease.
Researchers from La Jolla Institute for Allergy and Immunology in San Diego, Calif. report that they may have discovered a common driver associated with skin inflammation in both psoriasis and atopic dermatitis.
The findings of their investigation were published online in the May 22, 2017 edition of Nature Communications. The data showed that TWEAK, a protein related to tumour necrosis factor (TNF), plays a m...
Psoriasis patients who also have major depressive disorder (MDD) might be at risk of developing psoriatic arthritis, compared with psoriasis patients without MDD, according to findings published in the Journal of Investigative Dermatology (Apr. 2017; 137(4):828–835).
“For many years, the rheumatology and dermatology communities have been trying to understand which patients with psoriasis go on to develop psor...
Researchers from Swiss Tropical and Public Health Institute in Basel, Switzerland caution that residential radioactive gas radon exposure in Switzerland may increase a person’s risk developing malignant melanoma.