“The novelty is that [the new lipid vesicles] enable the absorption of a drug of greater size than usual through the skin and opens a route of administration of other substances for therapeutic, diagnostic or even vaccination purposes through the intact skin, without having to be injected," said lead author Ana Melero, PhD.
“These data demonstrate the therapeutic benefit of blocking Vegfa/Nrp1 interaction in the treatment of psoriatic disease, which may be safer for the treatment of psoriasis as compared to other therapeutic modalities that can be associated with serious side effects,” said Dr. Cédric Blanpain, the senior author of this study.
“Our initial finding that skin thickening in psoriasis is due to build-up of dysregulated stem cells and their progeny are exciting because it represents a new way of thinking about an old and significant skin disease.”
Findings from a survey distributed by the U.S. National Psoriasis Foundation show that many patients, unsatisfied with the results or side effects of their prescribed psoriasis treatments, are turning to complementary or alternative medicine.
“It is critical for both patients and doctors to understand the complexity of psoriasis. It is not just a skin disease; it is a serious condition that can affect all aspects of a patient’s health,” says Randy Beranek, president and CEO of the NPF in a press release. “Our goal in establishing these guidelines is to help health care professionals educate their patients on the best way to treat their disease an...
“In some diseases, cells lose their ability to differentiate, and reproduce more rapidly. Being able to redirect cells back to their usual life cycle could alleviate the processes behind the disease,” said Aditi Kanhere, PhD.
In studying the 7,794,087 patients included, significant associations were found between psoriasis and Crohn's disease as well as psoriasis and ulcerative colitis, finding that psoriasis patients had approximately twice the risk or probability of having Crohn's disease or ulcerative colitis.
For younger patients, appearance in social situations was a major motivating factor in seeking treatment for psoriasis. For older patients, improved sleep quality was a more important treatment outcome.These different goals need to be considered when creating treatment plans for patients.