“This study has implicated several new skin-related genes that impact on our vitamin D status—distinct from skin colour which affects our ability to make vitamin D depending on the concentration of the pigment melanin in the skin,” said senior author Professor John J. McGrath
The investigators observed significant improvements in sweat severity, skin-specific QoL, generalized anxiety, social anxiety, anxious/depressive symptoms, and social avoidance after one treatment. Further reduction in sweat and improved QoL were seen after two treatments.
“The study findings are interesting and may relate to bereaved people no longer having someone to help with skin examinations, leading to delays in diagnosis, although we cannot rule out stress being important in melanoma progression,” said senior author Sinéad Langan, PhD
Dr. Brian S. Kim said he believes that in addition to improving skin rash associated with AD, boosting the numbers of NK cells could help restore virus immunity in AD patients, noting that people who have very low numbers of NK cells tend to be more susceptible to the herpes virus, pox viruses and HPV viruses, among others.
“We found that the microbiome in epidermis is unique. It is very different depending on age and gender. On the other hand, the microbiome in dermis is the same—regardless of age and gender. This has not been shown before,” said co-author Lene Bay, in a press release. Bay is a postdoctoral researcher at the department of immunology and microbiology at the University of Copenhagen.
Rates of skin cancer were 8.1% among homosexual men and 8.4% among bisexual men, statistically higher than the rate of 6.7% among heterosexual men. Skin cancer rates were 5.9% among homosexual women and 6.6% among heterosexual women, which was not a statistically significant difference. However, the rate of 4.7% among bisexual women was statistically significantly lower than heterosexual women.
“This study represents an important milestone for the field of plasma medicine,” said co-senior author Richard Wirz, PhD, professor of mechanical and aerospace engineering at UCLA Samueli. “It demonstrates that the microneedle patch can realize the plasma delivery while also working with the drug to improve the effectiveness of cancer therapy.”
“The novelty is that [the new lipid vesicles] enable the absorption of a drug of greater size than usual through the skin and opens a route of administration of other substances for therapeutic, diagnostic or even vaccination purposes through the intact skin, without having to be injected," said lead author Ana Melero, PhD.